Abstract
Abstract: The synthesis of porphyrins with halogens and nitro groups in meso-aryl rings is described. Halo-substituted meso-tetraarylporphyrin derivatives in the reaction with sodium nitrite in trifluoroacetic acid at 40°C (or room temperature) afford 5-(4-nitroaryl)-10,15,20- triarylporphyrins. The above mono-nitro products bearing halogens on meso-aryl rings (F, Cl, Br) are difficult to obtain selectively. The method elaborated herein allows to synthesize them with reasonable yield (of up to 57%), and the reaction can be easily scaled-up. By this route, the preparation of valuable substrates for further transformation to highly substituted ‘synthetic porphyrins’ was presented.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.