Modification de l’épidémiologie des donneurs d’organes et nouvelles stratégies de préservation des greffons rénaux

Abstract

Changes in the epidemiology of brain death are leading the transplant community to use more marginal grafts from so-called extended criteria donors. Current preservation techniques, while simple, are no longer adequate for these organs, which harbor chronic lesions making them very sensitive to ischemia-reperfusion injury. New preservation solutions are needed, along with machine perfusion techniques (dynamic preservation) and normothermic preservation phases.