Abstract
The influence of fluoride (F(-)), bromide (Br(-)), iodide (I(-)), thiocyanate (SCN(-)) and nitrite (NO(2)(-)) on the reaction of a myeloperoxidase-H(2)O(2)-Cl(-) system with a nucleoside mixture was studied. The reaction was carried out under mildly acidic conditions and terminated by N-acetylcysteine. Without the additional anions, quantity of nucleosides consumed fell in the following order: 2'-deoxyguanosine>2'-deoxycytidine>>2'-deoxythymidine>2'-deoxyadenosine asymptotically equal to 0. F(-) did not affect the reaction. Br(-) increased the consumption of 2'-deoxycytidine and 2'-deoxythymidine, but decreased that of 2'-deoxyguanosine. I(-), SCN(-) and NO(2)(-) suppressed the reaction. These results suggest that Br(-) has a unique effect in relation to nucleoside damage caused by myeloperoxidase.
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