MODERN VIEWS ON THE TREATMENT OF NON-SPECIFIC VULVOVAGINITIS OF MIXED ETIOLOGY

Abstract

In the structure of gynecological morbidity, nonspecific vulvovaginitis of mixed etiology is becoming the most common pathology. Polymicrobial associations with varying degrees of etiological significance of the components are represented by both pathogenic and, mainly, opportunistic microorganisms. In 78% of cases with nonspecific vulvovaginitis, 2 or more pathogens are sown, which are capable of forming poly-species biofilms, which determines their high resistance to antibiotic therapy.The aim of the study was to evaluate the effectiveness of the modern antiseptic agent Ginodek in the treatment of nonspecific vulvovaginitis of mixed etiology.Material and research methods. There were 58 patients under observation with a verified diagnosis of nonspecific vulvovaginitis of mixed etiology. The exclusion criteria from the study were the detection of specific infections (gonorrhea, chlamydia, etc.). All women underwent clinical examination, bacterioscopic and bacteriological examination, and the pH of the vaginal secretion was determined. Patients with verified vulvovaginal infection received Ginodec - vaginal gel 5 ml once a day for 7 days. The effectiveness of treatment was assessed according to the data of clinical examination before treatment and on the 7th day of observation, as well as laboratory (bacterioscopic, bacteriological) data before and after treatment. The criteria for the effectiveness of treatment were complete clinical and bacterial sanitation: the absence of subjective clinical symptoms, inflammatory changes in the vaginal mucosa, and a negative result of microbiological examination of vaginal contents.Research results and their discussion. Bacteriological analysis of the microbial spectrum of the vagina of the examined women showed a different combination of 2 or more microorganisms. In addition, the overwhelming majority of patients (84.5%) had a sharp decrease in the number of lactobacilli (103 CFU / ml). After treatment with Gynodek vaginal gel, 5 ml once a day for 7 days, the objective and subjective symptoms of the inflammatory process of the vagina were completely arrested at the end of therapy. The results of bacteriological examination 2 weeks after the treatment also confirmed the effectiveness of using the Ginodek vaginal gel in most (94.8%) women, and lactobacilli in the amount of 107 CFU / ml were found in 86.2% of the examined.Conclusions. The drug Ginodec is highly effective against the main causative agents of nonspecific vulvovaginitis of mixed etiology, which makes it the drug of choice for local therapy. Gynodek does not affect the functional activity of lactobacilli, provides a comfortable pH of the environment, which contributes to the rapid restoration of the normal vaginal biotope.