Abstract
The incidence of basal cell skin cancer is increasing worldwide. The initiation and progression of basal cell skin cancer is due to the interaction of environmental factors and the patient's genetic characteristics. Aberrant activation of the transmission of the Hedgehog signaling pathway is the main pathogenetic pathway of carcinogenesis.
 Since basal cell skin cancer is manifested by significant variability of morphological structure, aggressiveness and response to treatment, the disclosure of the molecular genetics of pathogenesis will become the basis for developing new approaches and increasing the effectiveness of treatment, as well as overcoming tumor resistance to treatment.
 To search for the necessary literature, the PubMed, MedLine, Web of Science and RSCI databases were used.
Highlights
The incidence of basal cell skin cancer is increasing worldwide
The initiation and progression of basal cell skin cancer is due to the interaction of environmental factors and the patient's genetic characteristics
Since basal cell skin cancer is manifested by significant variability of morphological structure, aggressiveness and response to treatment, the disclosure of the molecular genetics of pathogenesis will become the basis for developing new approaches and increasing the effectiveness of treatment, as well as overcoming tumor resistance to treatment
Summary
The incidence of basal cell skin cancer is increasing worldwide. The initiation and progression of basal cell skin cancer is due to the interaction of environmental factors and the patient's genetic characteristics. For citation: Kubanov AA, Kondrakhina IN, Plakhova XI, Saytburkhanov RR. Аберрантная активация передачи сигнального пути Hedgehog является основным патогенетическим путем развития базальноклеточного рака кожи, а изучение его значимых звеньев является первым шагом к разработке и внедрению новых терапевтических подходов для лечения пациентов с базальноклеточным раком кожи.
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