Abstract
Commercialization of columns that provide multiple modes of chromatographic separations have recently been on the rise. For example, combinations of retention modes, such as ion-exchange and reversed-phase, often enable the separation of complex mixtures of analytes not possible using single-mode columns. In this work, recent trends in what is often referred to as “mixed-mode” phase are investigated. Particular attention is paid to recent fundamental research, stationary phase development and design, and areas of application.
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