Modern strategies and prospects for the treatment of ulcerative colitis

Abstract

The selecting tactics for managing patients with ulcerative colitis, an individual approach is required for each patient, depending on the activity and duration of the disease, as well as on the response to previous therapy.It is well known that the gut microbiome has a profound impact on the pathogenesis of infl ammatory bowel disease (IBD). The IBD gut microbiome is generally characterized by reduced species richness and diversity, less temporal stability, decreased benefi cial bacteria, and increased pathogenic bacteria.A search is underway for new opportunities to infl uence the microbiota, the virome of patients to achieve remission or prevent the development of this pathology. After all, earlier, more aggressive management of patients using targeted drugs can dramatically change the course of the disease and reduce the likelihood of relapses, complications, the need for hospitalization and surgical intervention.A better understanding of the human gut microbiome could provide innovative targets for prognosis, treatment, and even cure for this topical disease.