Modern possibilities of preterm birth prediction

M Hychka,O A Dyndar,V O Beniuk,V M Goncharenko,V F Oleshko

doi:10.18370/2309-4117.2020.51.56-59

Abstract

Purpose of the study is to improve the method of preterm deliveries onset predicting in pregnant women at 24–34 weeks.Materials and methods. 49 pregnant women with gestational age 24–34 weeks and with diagnosis of “threatening premature deliveries" were comprehensively examined using transvaginal ultrasound. Pregnant women with a shortened cervix ≤25 mm were given a qualitative determination of fetal fibronectin. The average age of pregnant women ranged from 26–34 years and averaged out 31.2 ± 0,6 years.Study results. Clinically significant structural changes in the cervix were only in 21 (42.9%) pregnant women. The average value of the cervix length varied between 16–24 mm and averaged 18.2 ± 0.4 mm. Positive test on fetal fibronectin in vaginal secretions was in 7 (33.3%) of 21 pregnant women with clinically significant structural changes in the cervix. During 10 days premature birth occurred in 3 (42.9%) of 7 pregnant women with clinically significant cervix shortening and a positive test for fetal fibronectin in the gestation period of 32 weeks. Hospitalization in an obstetric hospital was found to be unjustified in 28 (57.1%) cases.Conclusions. Combination of a comprehensive assessment of the cervix state and vaginal fetal fibronectin evaluation in pregnant women with risk of preterm deliveries at the outpatient stage allows to predict the manifestation of preterm birth in critical terms also determine the volume and direction of therapy in obstetric department. Combination of this methods help to prevent unwarranted hospitalization of a pregnant woman in an obstetric hospital and as a result it limits the conduct of glucocorticoid therapy and prevent a prolong stay of a pregnant woman in a hospital and the associated contamination with nosocomial bacteria strains.

Highlights

Premature birth is one of the most important problems in maternal and child health, as it directly affects perinatal morbidity and perinatal mortality
Even the highest quality treatment and nursing do not always save premature newborns, especially those born with extremely low body weight, from the prospect of disability [1, 9, 18]
At the same time, increased alertness of doctors in the aspect of possible premature deliveries, often leads to unjustified hospitalization in the obstetric hospital of pregnant women after 22 weeks with complaints of aching pain in the lower abdomen or spastic pain, which can be most often caused by impaired intestinal motility

Summary

MODERN POSSIBILITIES OF PRETERM BIRTH PREDICTION

N.M. HYCHKA PhD, associate professor, Obstetrics and Gynecology Department No 3, Bogomolets National Medical University, Kyiv ORCID: 000-0001-9863-6207. V.O. BENYUK MD, professor, head of the Obstetrics and Gynecology Department No 3, Bogomolets National Medical University, Kyiv ORCID: 0000-0002-5984-3307. V.M. GONCHARENKO MD, professor, Obstetrics and Gynecology Department No 3, Bogomolets National Medical University, Kyiv ORCID: 0000-0002-8317-3737. O.A. DYNDAR MD, professor, Obstetrics and Gynecology Department No 3, Bogomolets National Medical University, Kyiv ORCID: 0000-0002-0440-0410. V.F. OLESHKO PhD, assistant, Obstetrics and Gynecology Department No 3, Bogomolets National Medical University, Kyiv ORCID: 0000-0003-2493-2892

INTRODUCTION

MATERIALS AND METHODS

Дискуссионные проблемы преждевременных родов и выхаживания детей с

Биохимические маркеры при прогнозировании

СУЧАСНІ МОЖЛИВОСТІ ПРОГНОЗУВАННЯ ПЕРЕДЧАСНИХ ПОЛОГІВ