Abstract
Aim: The purpose of the study was to evaluate the efficiency of using the osmotic laxative polyethyleneglycol 4000 (PEG) for treatment of constipation in children. Patients and methods : Under the medical practice, the 30-days course of osmotic laxative polyethyleneglycol 4000 (PEG) administration in compliance with instruction for use was scheduled for 31 children within the age group from 5 to 17 years (average age 10.0 ± 3.5 years) in order to treat the constipation. The progress of clinical presentation and electric activity indices in different regions of gastrointestinal tract was evaluated by method of Peripheral Electrogastroenterography (PEGEG). Results: Before the start of the study most children had reported the stool retention (90%), straining efforts (87%), constrained defecation (81%) and hard stool (77%). About 50% of children had reported the long time spent in the toilet (68%) and scybalous stool (55%). As a result of the treatment the stool frequency has normalized and other constipation presentations have significantly reduced in all patient. Large bowel eclectic activity indices indicated the continuous impairment of its content evacuation. Simultaneously, the progress evaluation of electric activity progress in different regions of gastrointestinal tract (Pi/PS) and the large bowel rhythmicity ratio (Kritm) indicated the improvement on its peristalsis contractility. The adverse undesired effects of medication intake were registered in no patients. Conclusion : PEG4000 is efficient and safe remedy for treatment of constipation inn children.
Highlights
ВВЕДЕНИЕ Запор — одно из самых распространенных заболеваний в педиатрической практике
Aim: The purpose of the study was to evaluate the efficiency of using the osmotic laxative polyethyleneglycol 4000 (PEG) for treatment of constipation in children
Before the start of the study most children had reported the stool retention (90%), straining efforts (87%), constrained defecation (81%) and hard stool (77%)
Summary
Aim: The purpose of the study was to evaluate the efficiency of using the osmotic laxative polyethyleneglycol 4000 (PEG) for treatment of constipation in children. В Ставрополе было проведено исследование по выявлению хронического запора у 267 детей в возрасте от 1 мес до 7 лет. В результате анкетирования, проведенного в детских поликлиниках Центрального, Северо-Западного, Южного, Сибирского и Уральского федеральных округов РФ, среди 2195 детей в возрасте от 0 до 17 лет частота функционального запора составила 53% [8]. Для детей до 4 лет с недостаточными критериями для постановки диагноза «Синдром раздраженного кишечника» симптомы, наблюдающиеся по крайней мере 1 раз/нед в течение не менее 2 мес до постановки диагноза: — 2 и менее дефекации в нед; — по крайней мере 1 эпизод недержания в нед; — случаи насильственного сдерживания процесса дефекации; — эпизоды болезненной дефекации или твердого стула; — присутствие большого количества каловых масс в прямой кишке; — случаи дефекации большим объемом каловых масс, способных закупорить туалет. Начавшийся в раннем возрасте (менее 1 мес жизни) Отсутствие отхождения мекония в течение более 48 ч после рождения
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