Abstract
This study aims to improve methodological approaches for conducting research in real-world practice. As an example of a real-world study, we present a comparative study of the use of botulinum toxin type A drugs as a part of medical technology for the treatment of spasticity syndrome in children with cerebral palsy. The methodological approaches proposed in this study can become the basis for organizing and conducting comparative clinical trials of drugs of the same pharmacotherapeutic group and contribute to the formation of framework criteria for real-world studies. The introduction of integrative methodological approaches to clinical trials in practice is designed to optimize pharmacotherapy and improve the efficiency of the healthcare system.
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