Modern drug delivery formulations of potential anti-cancer herbal product

Abstract

Objectives: The objective of the present work is to formulate and evaluate lozenges of potassium salt of curcumin extract for the anticancer activity that delivers drug into buccal cavity. It aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidaemia. Curcumin lozenges were prepared for studying anticancer activity. Method: Solid dispersion of potassium curcuminate was prepared using β-cyclodextrin to enhance the solubility of potassium Curcuminate. The prepared solid dispersion of potassium Curcuminate was analysed for solubility enhancement. Curcuminate lozenges were then formulated with Potassium curcuminate, liquid glucose, sucrose and corn syrup by heat, and congealing technique. The prepared lozenges were evaluated for drug-excipient incompatibility study, colour, odour, taste and hardness. Results: The results of the compatibility study showed that there was no interaction between the selected drug and excipients. In-vivo studies of the lozenges were optimized based on in in-vitro drug release, drug Stability studies revealed that the formulation was stable Potassium curcuminate having greatest anticancer activity 85% towards prostate cancer cell, 80% towards liver cancer cell, and average of 92% towards colon cancer cell compared to curcumin and standard anticancer drugs like 5-Fu, Mito-C and Paclitaxel.