Modern diagnosis and treatment of growth hormone deficiency

Abstract

Pituitary dwarfism in recent years has become a completely treatable disease. Somatotropic insufficiency cannot be cured, but can be completely compensated by substitution therapy. With timely started and properly conducted treatment, persons with this disease can achieve normal growth and have a good quality of life. This is a huge achievement of modern medicine. In recent years, against the backdrop of the development of molecular genetics and genetic engineering, significant advances have been made in studying the mechanisms of expression and deciphering the structure of somatotropic hormone (STH) and STG receptor gene genes, and regulating the synthesis of various insulin-like growth factors (IGFs) and their binding proteins.