Abstract
The increasing demand on donor grafts has forced experimental research on transplantation medicine to develop more efficient organ preservation strategies. Simple cold storage of grafts rarely offers optimal conditions for extended criteria donor organs. Hypothermic, oxygenated machine perfusion (HMP) is aclassical method of dynamic organ preservation, which enables the provision of oxygen and nutrients to the tissue and provides ametabolic recovery of the graft prior to implantation. Amore modern approach is normothermic machine perfusion (NMP), which instead simulates physiological conditions and enables an ex vivo evaluation and treatment of organ grafts. However, studies have found that apreceding period of cold storage significantly mitigates the functional advantage of NMP. Astrategy to circumvent this phenomenon is controlled oxygenated rewarming (COR). The cold-stored graft is slowly and gradually rewarmed to subnormothermic or normothermic temperatures, providing agentle adaption of energy metabolism and counteracting events of rewarming injury.
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