Modern approaches to diagnosing and preventing malignization of peptic ulcer in the practice of the general practitioner from the perspective of evidence-based medicine

Abstract

Background: Peptic ulcer disease (PUD) is a prevalent gastrointestinal disorder that affects millions globally and has the potential to transform into gastric cancer (GC). GC ranks as the fifth most common cancer and is notably lethal. A significant correlation exists between PUD and Helicobacter pylori infection, which disrupts the stomach lining, leading to ulcers that may become malignant if not properly managed. Methods and Materials: This study employed a systematic analysis and meta-analysis approach, gathering data from multiple medical databases including Medscape, Medline, Scopus, Pubmed, and various gastrointestinal guidelines from regions such as Malaysia, Europe, and the United States. The primary methods involved comparing the risk of malignization between gastric and duodenal ulcers, assessing the sensitivity of different diagnostic methods, and determining optimal prevention strategies. Results: The findings indicate that gastric ulcers have a higher risk of malignization compared to duodenal ulcers. Diagnostic methods such as endoscopic biopsy demonstrated higher sensitivity for early malignization detection. Screening programs, especially those targeting H. pylori eradication, significantly reduce the incidence and mortality rates associated with gastric cancer. Conclusion: Early diagnosis and prevention of PUD malignization are vital for improving patient outcomes. Effective strategies include the use of sensitive diagnostic methods and comprehensive screening programs for H. pylori. Lifestyle modifications and vigilant monitoring by healthcare professionals are also crucial in reducing the risk of peptic ulcer malignization and subsequent gastric cancer development.