Abstract
Background: Exercise training is a beneficial treatment strategy for depression. Previous meta-analytical reviews mainly examined the effect of aerobic exercise on depressive symptoms neglecting comparisons with neuromuscular training and meta-regression considering relevant exercise training prescriptors such as exercise duration, intensity, number of exercise sessions (volume) and frequency.Methods: A structured literature search was conducted in biomedical and psychological databases and study selection was conducted following the PICOS approach. (Randomized) controlled trials that compared supervised neuromuscular or endurance exercise interventions with an inactive control group (CON) in clinically depressed in- or out-patients over 18 years were included. Eligibility and study quality were evaluated by two independent researchers. Standardized mean differences (SMD) for the reduction of depressive symptoms, measured with different evaluation scales (e.g., BDI, HAM-D, PHQ-9, HRSD, MADRS, GDS) were calculated with the adjusted Hedges'g equation as main outcome for the comparison of endurance and neuromuscular exercise interventions vs. CON. Statistical analyses were conducted using a random effects inverse-variance model. Multivariate meta-regression analysis was performed in order to examine the modulating effects of exercise training prescriptors.Results: Twenty seven trials with 1,452 clinically depressed adults were included. 20 out of 27 included trials reached a PEDro score of at least 6, representing high-quality. Irrespective of the exercise mode and study quality, large effects in favor of exercise compared to the control condition were found. Compared to CON, sensitivity analyses revealed a moderate to large effect in favor of endurance exercise [SMD: −0.79 (90% CI: −1.10, −0.48); p < 0.00001, I2 = 84%] and a large effect size in favor of neuromuscular exercise [SMD: −1.14 (90 CI: −1.50, −0.78); p < 0.00001, I2 = 80%]. These effects decreased to moderate for endurance and remained large for neuromuscular trials when considering studies of high quality, indicating a significant difference (p = 0.04). Multivariate meta- regression revealed that exercise duration in endurance trials and exercise intensity in neuromuscular trials had a significantly moderating effect.Conclusions: Strong neuromuscular exercise interventions can be slightly more effective than endurance exercise interventions. Interestingly, exercise duration and exercise intensity moderated the effect size meaningfully. This result might be used on exercise in depression to increase efficacy.
Highlights
Depression is considered a leading cause of disability worldwide and a major contributor to the overall global burden of disease [1]
A differentiation between neuromuscular and endurance exercise seems beneficial as patients do have different exercise preferences and both exercise modes cause different adaptations on behavioral and molecular level [24]
We found that exercise duration significantly moderates the effect of endurance interventions and exercise intensity moderates notably the effect of neuromuscular interventions
Summary
Depression is considered a leading cause of disability worldwide and a major contributor to the overall global burden of disease [1]. According to Ebmeier et al [2] and Halliwell et al [3], merely 18–25% of the depressed patients receive an adequate treatment with antidepressant medication and psychotherapy. The treatment with antidepressant medication is accompanied with poor compliance [4] and has been reported to cause several unintended side effects like withdrawal symptom [2], nausea, insomnia, anxiety [5], weight gain [6], or sexual dysfunction [7]. The WHO [8] and the NICE [9] guidelines recommend physical exercise as a standard complementary treatment option for depression. Exercise as a complementary treatment option provides various benefits such as decreased blood pressure [10], weight reduction [11], increased oxygen uptake [12, 13] while negligible side effects are known [11]. Previous meta-analytical reviews mainly examined the effect of aerobic exercise on depressive symptoms neglecting comparisons with neuromuscular training and meta-regression considering relevant exercise training prescriptors such as exercise duration, intensity, number of exercise sessions (volume) and frequency
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