Abstract
Aim. Up to now, an appropriate salt intake in renal insufficiency has not been clearly determined. We hypothesize that even a moderate decrease in salt intake may affect functional and morphologic response of the rat remnant kidney after 5/6 nephrectomy.Methods. Subtotal nephrectomy was performed in 77 inbred 12 week-old-female AVN Wistar rats. The two groups of rats were fed either a standard or a low salt diet. Median of salt intake was 14.6 and 10.4 mg/100 g/24 h in the two groups.Results. Ten weeks after ablation, the remnant kidney parenchyma wet weight was 0.66 ± 0.16 g/100 g of body weight and 0.56 ± 0.11 g/100 g of body weight (P<0.01) in rats with a standard and low salt diet, respectively. In these two groups, systolic blood pressure was 151 ± 29 versus 126 ± 21 mmHg (P<0.05), serum creatinine levels were 164 ± 84 versus 106 ± 29 µmol/L (P<0.001), proteinuria was 84 ± 37 versus 83 ± 40 mg/100 g/24 h (N.S.), and the glomerular injury score was 2.06 ± 0.49 versus 1.43 ± 0.62 (P<0.01), respectively.Conclusion. Moderately decreased salt intake slowed down the development of ablation nephropathy in AVN inbred strain of rats.
Highlights
Ablation of 5/6 (83%) of renal parenchyma in rats is an experimental model of chronic renal failure
The aim of the present study was to determine if even a mild decrease in salt intake (0.3% versus 0.5%), which corresponds by weight to the recommended salt intake in men (4-5 g/24 h), would affect functional and morphologic response of the rat remnant kidney after 5/6 nephrectomy
The current view of the renal disease progression in men was inferred from findings in the 5/6 nephrectomised rats
Summary
Ablation of 5/6 (83%) of renal parenchyma in rats is an experimental model of chronic renal failure. The final fatal consequence is the remnant glomeruli sclerosis, tubular atrophy and interstitial sclerosis (i.e., ablation nephropathy), and renal failure. This process can be reduced by a low protein diet and/or angiotensin converting enzyme inhibitors administration [1] or by the early kidney transplantation [2]. It is well known that low salt intake decreases systemic blood pressure in experimental animals and men [3,4,5,6,7] as well as the incidence of cardiovascular accidents [8]. Low salt intake suppresses asymmetric dimethylarginine (ADMA)
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