Abstract
Purpose: In vertebrate, the nucleus pulposus (NP), which is an essential component of the intervertebral disc (IVD), is constantly impacted by fluid shear stress (FSS); however, molecular mechanism(s) through which FSS modulates the NP extracellular matrix (ECM) homeostasis is poorly understood. Therefore, this study aimed to investigate the regulation effects of FSS on ECM homeostasis on NP cells and its molecular mechanism.
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