Abstract

We derive a moderate deviation principle for word counts (which is extended to counts of multiple patterns) in biological sequences under different models: independent and identically distributed letters, homogeneous Markov chains of order 1 and m, and, in view of the codon structure of DNA sequences, Markov chains with three different transition matrices. This enables us to approximate P-values for the number of word occurrences in DNA and protein sequences in a new manner.

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