Abstract

We present and analyze a mathematical model of the transmission dynamics of Contagious Bovine Pleuropneumonia (CBPP) in the presence of antibiotic treatment with limited medical supply. We use a saturated treatment function to model the effect of delayed treatment. We prove that there exist one disease free equilibrium and at most two endemic equilibrium solutions. A backward bifurcation occurs for small values of delay constant such that two endemic equilibriums exist if Rt (R*t,1); where, Rt is the treatment reproduction number and R*t is a threshold such that the disease dies out if and persists in the population if Rt > R*t. However, when a backward bifurcation occurs, a disease free system may easily be shifted to an epidemic. The bifurcation turns forward when the delay constant increases; thus, the disease free equilibrium becomes globally asymptotically stable if Rt < 1, and there exist unique and globally asymptotically stable endemic equilibrium if Rt > 1. However, the amount of maximal medical resource required to control the disease increases as the value of the delay constant increases. Thus, antibiotic treatment with limited medical supply setting would not successfully control CBPP unless we avoid any delayed treatment, improve the efficacy and availability of medical resources or it is given along with vaccination.

Highlights

  • Contagious Bovine Pleuropneumonia (CBPP) is a disease of cattle caused by Mycoplasma mycoides subspecies mycoides (Mmm) small colony that infect lungs of cattle and water buffalo [24]

  • We present a mathematical model of the transmission dynamics of CBPP considering antibiotic treatment within a limited medical supply setting as a controlling mechanism of CBPP

  • For b = 1, Figures 2–3 show that two endemic equilibriums exist for a ∈ (0.1049, 0.1377) or Rt ∈ (0.7898, 1) implying that the disease persists in the population if the maximal medical resource supply is below 0.1377

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Summary

Introduction

Contagious Bovine Pleuropneumonia (CBPP) is a disease of cattle caused by Mycoplasma mycoides subspecies mycoides (Mmm) small colony that infect lungs of cattle and water buffalo [24]. A deterministic mathematical model for the transmission of CBPP was presented to compare economic efficiency of local (i.e., at the herd level) CBPP-control strategies (vaccination and antibiotic treatments) in [15]. It revealed that antibiotics were the most economically efficient strategy than vaccination. Homogeneous and heterogeneous population models of the transmission dynamics of CBPP are presented in [19] and [20], respectively Both models indicated that vaccination alone with currently available vaccines was unlikely to eradicate the disease.

Basic assumptions and parameters
A mathematical model
Equilibrium solution of the system
Stability analysis of equilibrium solutions
Numerical simulations
Findings
Discussion and conclusions
Full Text
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