Abstract
This chapter discusses the prolonged effects of neonatal pain. A substantial inflammatory response lasting for 2 weeks follows from a single injection of 2% carageenan into one hindpaw within 24 h of birth. This causes no lasting effect on behavioral sensory thresholds or inflammatory pain responses in adulthood. It is important to emphasize, however, that electrophysiological and neuroanatomical analysis may reveal changes in sensory connections that are not evident in reflex behavioral tests and that more research is required in this area. In addition, the reapplication of 2% carageenan or complete Freunds adjuvant (CFA) in rats, when they had reached maturity, caused normal inflammatory, hyperalgesic, and allodynic responses that did not differ from controls. Repetitive painful experiences, prolonged tissue or nerve damage in newborn rats can lead to long-lasting neurobehavioral sequelae not observed when the same stimuli are applied to adults.
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