Abstract

This work presents an idealized geometric model of the lymph node (LN) consisting of a set of 'elementary' macroscopic structures such as subcapsular sinus, trabecular sinuses with a special focus on fibroblastic reticular cells (FRC) network. An experimental data driven computational algorithm has been developed to reconstruct the macroscopic structure of FRC network based on high-resolution confocal microscopy data of a murine LN. The FRC geometric model can be further discretized for use in computational studies of lymph and cytokines transport through the LN.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call