Abstract
Event Abstract Back to Event Modelling the effects of slow wave sleep on synaptic plasticity Michael Schellenberger Costa1*, Daphne Krioneriti1, 2, Jens Christian Claussen1, Lisa Marshall3 and Thomas Martinetz1 1 University of Lübeck, Institute for Neuroinformatics, Germany 2 Graduate School for Computing in Medicine and Life Science, Germany 3 University of Lübeck, Institute for Neuroendocrinology, Germany Multiple studies have shown the importance of slow wave sleep for the development of memories. Furthermore slow oscillatory activity can be modulated by non-invasive stimulation, which leads to an enhancement of memory consolidation. However the exact mechanisms remain unknown. Here we combine a biophysical model of up/down state generation proposed by Compte et al. with a Ca2+-dependent plasticity rule Bhalla et al. as the first step towards developing a model for long-term plasticity during slow wave sleep. We show that the synaptic efficacy is indeed elevated after one up/down cycle and keeps increasing with every further cycle, approaching the stable potentiated state. However the number of up/down states needed to push the synapse in the strong state is far from the one seen in natural slow wave sleep. As the plasticity model focuses solely on single synapses we investigate the effect of additional downstream plasticity related proteins and kinases e.g. MAPK, which are know to play a crucial role in LTP and link the cell wide activation by the up/down states to the plasticity of the individual synapses. References A. Compte, M.V. Sanchez-Vives, D.A. McCormick, and X.-J. Wang. Cellular and network mechanisms of slow oscillatory activity (<1 Hz) and wave propagations in a cortical network model. Journal of neurophysiology, 89(5):2707--25, May 2003. Upinder S Bhalla. Multiscale interactions between chemical and electric signaling in LTP induction, LTP reversal and dendritic excitability. Neural networks : the official journal of the International Neural Network Society, 24(9):943--949, May 2011. Keywords: Calcium, MAPK, slow wave sleep, synaptic plasticity Conference: Bernstein Conference 2012, Munich, Germany, 12 Sep - 14 Sep, 2012. Presentation Type: Poster Topic: Learning, plasticity, memory Citation: Schellenberger Costa M, Krioneriti D, Claussen J, Marshall L and Martinetz T (2012). Modelling the effects of slow wave sleep on synaptic plasticity. Front. Comput. Neurosci. Conference Abstract: Bernstein Conference 2012. doi: 10.3389/conf.fncom.2012.55.00203 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 May 2012; Published Online: 12 Sep 2012. * Correspondence: Mr. Michael Schellenberger Costa, University of Lübeck, Institute for Neuroinformatics, Lübeck, 23538, Germany, schellenberger@inb.uni-luebeck.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Michael Schellenberger Costa Daphne Krioneriti Jens Christian Claussen Lisa Marshall Thomas Martinetz Google Michael Schellenberger Costa Daphne Krioneriti Jens Christian Claussen Lisa Marshall Thomas Martinetz Google Scholar Michael Schellenberger Costa Daphne Krioneriti Jens Christian Claussen Lisa Marshall Thomas Martinetz PubMed Michael Schellenberger Costa Daphne Krioneriti Jens Christian Claussen Lisa Marshall Thomas Martinetz Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.