Abstract
Cancer is a leading cause of death worldwide and it is caused by the interaction of genomic, environmental, and lifestyle factors. Although chemotherapy is one way of treating cancers, it also damages healthy cells and may cause severe side effects. Therefore, it is beneficial in drug delivery in the human body to increase the proportion of the drugs at the target site while limiting its exposure at the rest of body through Magnetic Drug Targeting (MDT). Superparamagnetic iron oxide nanoparticles (SPIONs) are derived from polyol methods and coated with oleic acid and can be used as magnetic drug carrier particles (MDCPs) in an MDT system. Here, we develop a mathematical model for studying the interactions between the MDCPs enriched with three different diameters of SPIONs (6.6, 11.6, and 17.8 nm) in the MDT system with an implanted magnetizable stent using different magnetic field strengths and blood velocities. Our computational analysis allows for the optimal design of the SPIONs enriched MDCPs to be used in clinical applications.
Highlights
Cancer is a leading cause of death worldwide
In order to optimize the size of the Superparamagnetic iron oxide nanoparticles (SPIONs) in the content of magnetic drug carrier particles (MDCPs) in an SA-Magnetic Drug Targeting (MDT) system, a 2D mathematical model was developed based on a previous model [18]
We model the behaviour of N MDCPs under the influence of (i) Stokes drag, (ii) hydrodynamic interaction forces, and (iii) magnetic forces that account for the mutual magnetic dipole-dipole interactions and calculated (iv) the velocity of each MDCP and MDCPn and (v) the system performance in terms of collection efficiency (CE) ignoring the effect of inertia and gravity (Figure 1)
Summary
Cancer is a leading cause of death worldwide. Its cause is multifactorial and is linked to the interaction of genomic, environmental, and lifestyle factors [1]. MDT refers to the attachment of therapeutics to magnetizable particles to concentrate them at the desired locations by applying magnetic fields [8] It includes the investigation of an external magnetic field and its interaction with biocompatible magnetic drug carrier particles (MDCPs) [9]. This makes MDCP collection problematic, because the magnetic force on a MDCP is proportional to the magnitude of the magnetic field and to its gradient To overcome these limitations, soft ferromagnetic materials such as wires, seeds, and stents are implanted into the body to increase the localized magnetic field strength and gradient, and this technique is called Implant Assisted Magnetic Drug Targeting (IA-MDT) [12,13,14,15]. The quantity of the carrier particles at the desired site under the influence of four different magnetic field strengths and four different blood velocities is considered
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
