Abstract
community, and we provide a simple interface based on parameter specification so that VERTEX can be used even by non-programmers. Code vectorisation and parallelisation methods allow VERTEX to simulate networks containing hundreds of thousands of reduced compartmental neurons in reasonable time .W e demonstrate how VERTEX can be used to simulate LFPs at hundreds of locations in a large-scale, spatially organised cortical network model, and how these results can be used in conjunction with experimental data, by comparing simulation results with MEA recordings of persistent gamma oscillations made in macaque neocortical tissue in vitro.
Highlights
Local field potentials (LFPs), measured using extracellular electrodes, provide information about local neuronal population activity
We investigated reduced compartmental models to assess their suitability for producing realistic spatial LFP characteristics
We show that the chosen reduction method [3] creates compartmental models that preserve essential spatial LFP features, while being computationally cheap enough for large network simulations
Summary
Local field potentials (LFPs), measured using extracellular electrodes, provide information about local neuronal population activity. We describe two contributions to the effort to understand LFP generation in neuronal networks.
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