Abstract
Models describing the concomitant effects of pH and organic modifier concentration on retention in reversed-phase liquid chromatography are established. Two different octadecyl-modified silica columns were used. The retention behaviour of several acidic, basic and neutral solutes were studied, using methanol as the organic modifier. The suggested models accurately describe retention as a function of pH and composition. A unified formalism for retention modelling that is applicable to all ionogenic solutes is also established. This formalism is tested with the modelling of retention for several weak bases. The resulting (general) model describes retention accurately and is applicable to all solutes studied.
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