Abstract
Crystal size distribution has received extensive attention because of its influence on the crystal performance. Crystal size distribution is closely related to the crystallization mode. What’s more, it is susceptible to the operation conditions of crystallization process, such as temperature and the flow rate of anti-solvent. In view of the selection of crystallization mode, the crystal size distribution model of $\gamma$-aminobutyric acid crystallization process was established. The model consists of solubility equation, nucleation rate equation, growth rate equation, crystal balance equation and mass balance equation. For $\gamma$-aminobutyric acid solubility equation, based on the study of the thermodynamic properties, taking into account the effects of temperature and ethanol content, the empirical equation of temperature and ethanol content was established. For the numerical simulation of crystallization process, the crystal size distribution and yield of crystal were studied under different ways of cooling, anti-solvent, and cooling-dissolving. The results of experimental study showed that the model and simulation method can reflect real crystallization process well. Furthermore, mean crystal size and yield of crystal could be improved by cooling combined with anti-solvent crystallization.
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