Abstract
A problem of optimal assembly from magnets modelling for steering of magnetic nanoparticles in a closed environment containing a stream of close-to-blood liquid is considered in this research. The targeting assembly from magnets is designed based on Halbach arrays and contains 18 permanent magnets forming a movable and a stationary block of the targeting part of a magnetic drug delivery device. The injected particles were diverted from their flow path near the vicinity of movable part of assembly from magnets while not aggregating thereat, but migrating to the target zone under the stationary part of the said assembly. Minimum magnetic force value was established for the injected particle path manipulation towards the target area. DOI: http://dx.doi.org/10.5755/j01.mech.23.6.19645
Highlights
Research on magnetic drug targeting as a therapeutic technique, which requires guidance of drug carriers to specific sites in a manner such that its major fraction interacts exclusively with a target tissue at the cellular or subcellular level is receiving more and more attention [1,2,3]
Applied magnetic field and magnetic field gradient decrease rapidly with increase of distance from magnets; insufficient reach is one of the major limits of the applicability of magnetic drug delivery [2, 6, 11,12,13,14,15,16,17]. It is still a technically challenging task to build up sufficient field strength that would sufficiently focus drug carriers on a small area and would be able to counteract the linear blood-flow rates acting on said drug carriers in blood vessels
Main research idea was to investigate the assembly from magnets for magnetic drug targeting (MDT) device and whether the device generates sufficient magnetic field force on particles for them to be able to compete with convective blood force that tend to wash particles away
Summary
Research on magnetic drug targeting as a therapeutic technique, which requires guidance of drug carriers to specific sites in a manner such that its major fraction interacts exclusively with a target tissue at the cellular or subcellular level is receiving more and more attention [1,2,3]. The focused administration of drugs is carried out by use of magnets to direct drug carriers of appropriate size and magnetic properties to specific sites in human body to treat tumours, infections, blood clots, for local hyperthermia and other [49]. Such administration can reduce unwanted distribution of drugs minimizing side effects such as caused by systematically administered chemotherapy [10]. Attention in this paper has been focused to the issue of lack of sufficiently large magnetic field gradient at a certain distance from its source
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