Abstract
© 2015 Metzner et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Highlights
Abnormal oscillatory activity in schizophrenia has been found in a wide range of experimental paradigms [1]
Similar to previous approaches [6], focusing on evoked rather than spontaneous activity, we explored the effects of (1) connectivity disturbances (reduced (a) recurrent excitation, (b) pyramidal cell input and (c) total connectivity), (2) prolonged GABAergic decay time constant, and (3) reduced inhibitory output
A prolonged GABAergic decay time constant produced a reduction of power at 40 Hz and an increase in power at 20 Hz, for the 40 Hz drive
Summary
Abnormal oscillatory activity in schizophrenia has been found in a wide range of experimental paradigms [1]. We used the primary auditory cortex model from Beeman [3] and simulated click train stimulation at 40 Hz, to investigate gamma entrainment deficits, and at 30 Hz as a control condition. Without alterations the model entrained at the driving frequency of 30 and 40 Hz, respectively.
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