Abstract
Objective: It has been previously shown that high-frequency ultrasound (20–100 MHz) can be used to detect cellular structure changes, including apoptosis, in tissues and cell ensembles. The detection of apoptosis is based on changes in the intensity and frequency spectrum of the backscattered ultrasound. However, as these changes in backscatter are not fully understood, it is not possible to accurately measure the apoptotic index, the percentage of cells in a volume undergoing apoptosis. Measuring the apoptotic index with high-frequency ultrasound would have implications in a broad range of fields, from cancer treatment monitoring to organ transplantation. We are investigating the use of an ultrasound scattering model of cell ensembles in deducing the apoptotic index.
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