Abstract
ABSTRACTExperimental results for flocculation of yeast and CHO cells using cationic polyelectrolytes are presented. These results suggest the existence of a self-similar floc size distribution. The experimentally determined floc size distributions have been modelled using a population balance approach. For flocculated yeast suspensions, the variation of the floc volume fraction with dimensionless particle diameter is predicted by the population balance model assuming a binary fragment distribution function. However, for CHO cell flocs, the floc volume fraction is predicted using a log normal fragment distribution function. Since the efficiency of unit operations such as microfiltration may be improved by flocculation of the feed suspension characterization of the particle size distribution is of great importance.
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