Abstract
AbstractDrugs producing CNS behavioural effects induce consistent changes in EEG frequency modulated electrical fields. Current models which use spike potential theories of neural conduction to explain EEG frequency changes and effects have limitations and are not consistent with some experimental data. An electrophysiologic framework exists at the neuronal membrane capable of responding to extracellular electrical fields to produce changes in cellular ion concentrations and result in ATP production. Models based on active EEG effects can be utilized to explain correlations between drug behavioural effects and spatial and frequency characteristics of the EEG. Such modelling is consistent with data derived from PET scanning of the CNS, and suggests that topographic mapping of physiologic variations in EEG frequencies may be increasingly useful in the evaluation of CNS pathology.
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