Abstract
Modelling acute leukemias in mice: clonal evolution and the emergence of leukemic stem cells.
Highlights
The concept of cancer stem cells (CSCs) has come from pioneering studies on acute myeloid leukemia (AML) which have defined a distinct subpopulation of tumour cells, the leukemia initiating cells (LICs), characterized by their capacity to initiate the disease when transplanted into imuno-deficient mice [2,3]
The situation is different in paediatric acute lymphoblastic leukemia (ALL), where there is evidence that leukemia initiating activity is observed in the immature cell population and in populations corresponding to a range of normal precursor cells [9,10]
It has been recently shown that the overexpression of the LMO2 oncogene in the thymus induce the emergence of a preleukemic stem cell population [20] but the identification of the cell of origin of T-acute lymphoblastic leukemia (T-ALL) and the mechanisms by which these oncogenes reprogram normal thymocytes to become T-LIC remain unclear
Summary
The concept of CSCs has come from pioneering studies on acute myeloid leukemia (AML) which have defined a distinct subpopulation of tumour cells, the leukemia initiating cells (LICs), characterized by their capacity to initiate the disease when transplanted into imuno-deficient mice [2,3]. * Correspondence: trang.hoang@umontreal.ca 1Institute of Research in Immunology and Cancer, University of Montréal, Montréal, Québec, Canada H3C 3J7 Full list of author information is available at the end of the article self-renewal [6,7]. The situation is different in paediatric acute lymphoblastic leukemia (ALL), where there is evidence that leukemia initiating activity is observed in the immature cell population and in populations corresponding to a range of normal precursor cells [9,10].
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