Abstract
The concentrations of various complexes and self-associated species at equilibrium is modeled by the evaluation of multiple simultaneous equations. The application of these general methods to the self-assembly of DNA base pairs and their analogs in chloroform solution is described. The specificity of the self-assembly can be quantified by measuring the system's fidelity, defined as the ratio of the concentration of desired complexes to the concentration of all complexes. Fidelity is shown to be a generally useful quantity to measure the degree to which supramolecular recognition units associate without interfering with the assembly of other modules (orthogonal recognition). The examples in this article as well as the detailed derivations included in the online material, represent a starting point for anyone who would like to incorporate the modeling of complex supramolecular equilibria in their teaching and research.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
