Abstract
Cardiac calsequestrin (CASQ2), a Ca buffer localized to the junctional SR (jSR) of cardiac myocytes, is known to bind to the RyR-triadin-junctin complex, participate in the luminal regulation of RyRs, and modulate Ca spark activity. To investigate the functional role of CASQ2 during spontaneous Ca sparks, we constructed a hybrid CTMC-ODE stochastic simulation of a Ca release site model composed of 100 Lee-Keener RyRs [J. Theor. Biol. 253:668-679, 2008] that includes Ca activation, Ca inactivation, CASQ2-RyR binding, and the dynamics of myoplasmic and luminal domain Ca and buffer concentrations.
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