Abstract
BackgroundAs magnetoencephalography (MEG) is of increasing utility in the assessment of deficits and development delays in brain disorders in pediatrics, it becomes imperative to fully understand the functional development of the brain in children.MethodologyThe present study was designed to characterize the developmental patterns of auditory evoked magnetic responses with respect to age and gender. Sixty children and twenty adults were studied with a 275-channel MEG system.ConclusionsThree main responses were identified at approximately 46 ms (M50), 71 ms (M70) and 106 ms (M100) in latency for children. The latencies of M70 and M100 shortened with age in both hemispheres; the latency of M50 shortened with age only in the right hemisphere. Analysis of developmental lateralization patterns in children showed that the latency of the right hemispheric evoked responses shortened faster than the corresponding left hemispheric responses. The latency of M70 in the right hemisphere highly correlated to the age of the child. The amplitudes of the M70 responses increased with age and reached their peaks in children 12–14 years of age, after which they decreased with age. The source estimates for the M50 and M70 responses indicated that they were generated in different subareas in the Heschl's gyrus in children, while not localizable in adults. Furthermore, gender also affected developmental patterns. The latency of M70 in the right hemisphere was proposed to be an index of auditory development in children, the modeling equation is 85.72-1.240xAge (yrs). Our results demonstrate that there is a clear developmental pattern in the auditory cortex and underscore the importance of M50 and M70 in the developing brain.
Highlights
The maturational changes and developmental abnormalities of the auditory system can be detected with magnetoencephalography (MEG) [1]
An earlier component of the middle latency components of auditory evoked fields (AEFs)( or M50), is somewhat less studied, predominantly due to the fact that it tends to be smaller in amplitude and less reliably observed in adults [4,5]
To analyze the left and right responses individually, the MEG channels were separated into two groups: the left group covered the left hemisphere and the right group covered the right hemisphere
Summary
The maturational changes and developmental abnormalities of the auditory system can be detected with magnetoencephalography (MEG) [1]. Neuromagnetic responses in the auditory cortex to an auditory stimulus, termed auditory evoked fields (AEFs) include several components. A component approximately 100 ms after stimulus presentation (or M100) has been considered the most prominent response in the auditory system in adults [2]. Intracerebral recordings have demonstrated that the M50 is probably a complex that includes two subcomponents: Pb1 and Pb2 [6]. It remains unclear; if and how the Pb1 and Pb2 subcomponents change in the developing brain. As magnetoencephalography (MEG) is of increasing utility in the assessment of deficits and development delays in brain disorders in pediatrics, it becomes imperative to fully understand the functional development of the brain in children
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