Abstract
Acute mucositis is the most important dose-limiting side effect to the escalation of radiotherapy or chemoradiation in the treatment of locally advanced head and neck cancer. In randomized studies chemoradiation significantly enhances the rate of Grade 3 and 4 mucositis; but so does radiation dose escalation. Published methodology for modeling the contribution of chemotherapy to the observed increase in local control can be used to make the same estimate for acute mucositis. The purpose of this study was to model the contribution of synchronous chemotherapy on the rate of Grade 3 and 4 mucositis and compare it with the effect of radiotherapy dose escalation.
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