Modeling the 3D-structure of the ZAP-70-VAV-SLP-76 Complex Required for T cell Receptor Function

Abstract

Zap-70 is a key kinase in the regulation of the adaptive immune responses. Zap-70 transmits T-cell activation signals induced by the interaction of Major Histocompatibility Complexes with T-cell Receptors. Phosphorylation of SLP-76 by the ZAP-70 kinase mediated by adaptor protein Vav is required for T-cell Receptor function. This study employs tools of structural bioinformatics to elucidate the structural basis of the Vav-mediated phosphorylation of SLP-76.