Abstract
Editorial summaryOur understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.
Highlights
Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed
Research using animal models has provided insights into the neural mechanisms underlying endophenotypes, such as quantifiable components of the genes-to-behavior pathways associated with psychiatric disorders, but how precisely these findings can be extrapolated to human mental health remains difficult to assess [3]
IPSC clones can be differentiated to any other cell type by exposure to an appropriate combination of patterning molecules
Summary
Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. The iPSC toolkit to capture genetic complexity Even as neuropsychiatric research has boomed, psychiatric disorders have remained a leading cause of global morbidity and disease burden [1]. Research using animal models has provided insights into the neural mechanisms underlying endophenotypes, such as quantifiable components of the genes-to-behavior pathways associated with psychiatric disorders, but how precisely these findings can be extrapolated to human mental health remains difficult to assess [3].
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