Abstract
Changes in synaptic efficacies need to be long lasting in order to serve as a substrate for memory. Experimentally, synaptic plasticity exhibits phases covering: i) the induction of long-term potentiation and depression (LTP/LTD) during the early phase of synaptic plasticity, ii) the setting of synaptic tags, a trigger process for protein synthesis, and iii) a slow transition leading to synaptic consolidation during the late phase of synaptic plasticity. We present a mathematical model that describes these different phases of synaptic plasticity. The model explains a large body of experimental data on synaptic tagging and capture, cross tagging, and the late phases of LTP and LTD. Moreover, the model accounts for the dependence of LTP and LTD induction upon voltage and presynaptic stimulation frequency. The stabilization of potentiated synapses during the transition from early to late LTP occurs by protein synthesis dynamics that is shared by groups of synapses. The functional consequence of this shared process is that previously stabilized patterns of strong or weak synapses onto the same postsynaptic neuron are well protected against later changes induced by LTP/LTD protocols at individual synapses. Moreover, the protein synthesis being triggered by a dopamine signal, we establish a link between this neuromodulator and the reward prediction error of reinforcement learning models. See Figure 1. from Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Berlin, Germany. 18–23 July 2009
Highlights
Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Don H Johnson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2202-10-S1-info.pdf
Synaptic plasticity exhibits phases covering: i) the induction of long-term potentiation and depression (LTP/LTD) during the early phase of synaptic plasticity, ii) the setting of synaptic tags, a trigger process for protein synthesis, and iii) a slow transition leading to synaptic consolidation during the late phase of synaptic plasticity
We present a mathematical model that describes these different phases of synaptic plasticity
Summary
Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Don H Johnson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2202-10-S1-info.pdf . Email: Wulfram Gerstner* - wulfram.gerstner@epfl.ch * Corresponding author from Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Berlin, Germany.
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