Abstract
We used size distributions of volume equivalent spherical particles with complex refractive index to model the inherent optical properties (IOPs) in four different layers of human skin at ten different wavelengths in the visible and near-infrared spectral bands. For each layer, we first computed the size-averaged absorption coefficient, scattering coefficient, and asymmetry factor for the collection of particles in a host medium using Mie theory and compared these IOPs in each layer with those obtained from a bio-optical model (BOM). This procedure was repeated, using an optimization scheme, until satisfactory agreement was obtained between the IOPs obtained from the particle size distribution and those given by the BOM. The size distribution as well as the complex refractive index of the particles, obtained from this modeling exercise, can be used to compute the phase matrix, which is an essential input to model polarized light transport in human skin tissue.
Highlights
The group of optics and atomic physics at the Department of Physics and Technology, University of Bergen has been actively involved in research and development of non-invasive biomedical techniques to identify early stage malignant melanomas from non-malignant or benign skin lesions
Such optical diagnostic technique [1, 2] relies on scalar radiative transfer theory, which has been developed and extensively used in the field of atmospheric remote sensing based optical satellite measurements
The only important difference between these two systems is that the skin is a moderately denser optical medium than the ocean, implying that existing radiative transfer models for coupled atmosphere-ocean remote sensing can be applied to an air-skin system with some adjustments [3, 4]
Summary
The group of optics and atomic physics at the Department of Physics and Technology, University of Bergen has been actively involved in research and development of non-invasive biomedical techniques to identify early stage malignant melanomas from non-malignant or benign skin lesions. Such optical diagnostic technique [1, 2] relies on scalar radiative transfer theory, which has been developed and extensively used in the field of atmospheric remote sensing based optical satellite measurements. The goal of this thesis is intended to investigate skin optics relevant for the transport of polarized light into the layered structure of human skin
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