Abstract
The mechanism of interaction between a cell and an external mechanical field is still poorly understood, and the accumulated diverse experimental data are often scattered. Therefore, the aim of this work was to systematize the experimental data in a mathematical model of the interaction between a cell and an external mechanical field based on standard kinetic equations and Fick’s diffusion equation. Assuming that the cortical cytoskeleton proteins play a key role in cell mechanosensitivity, we compared the results of mathematical modeling and experimental data concerning the content of cytoskeletal proteins at the early stages of a mechanical field change. In addition, the proposed mathematical model suggests the dynamics of changes of a key transcription factor, which is necessary for the expression of certain genes encoding cytoskeletal proteins.
Highlights
Human exploration of outer space faces a number of unsolved problems, including medical problems
The aim of this work was to systematize the experimental data in a mathematical model of the interaction between a cell and an external mechanical field based on standard kinetic equations and Fick’s diffusion equation
Assuming that the cortical cytoskeleton proteins play a key role in cell mechanosensitivity, we compared the results of mathematical modeling and experimental data concerning the content of cytoskeletal proteins at the early stages of a mechanical field change
Summary
Human exploration of outer space faces a number of unsolved problems, including medical problems. Being in conditions of weightlessness, even during Earth orbit, leads to a number of negative effects, for example, on the musculoskeletal and cardiovascular systems [1] [2] [3]. For the most part, are palliative, which is associated with a lack of un-. Questions remain about the interaction of a cell and a gravitational field: what is the mechanosensor and how the mechanotransduction paths are started
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