Modeling of the PHEMA-gelatin scaffold enriched with graphene oxide utilizing finite element method for bone tissue engineering

Abstract

The development of computer-aided facilities has contributed to the optimization of tissue engineering techniques due to the reduction in necessary practical assessments and the removal of animal or human-related ethical issues. Herein, a bone scaffold based on poly (2-hydroxyethyl methacrylate) (PHEMA), gelatin and graphene oxide (GO), was simulated by SOLIDWORKS and ABAQUS under a normal compression force using finite element method (FEM). Concerning the mechanotransduction impact, GO could support the stability of the structure and reduce the possibility of the failure resulting in the integrity and durability of the scaffold efficiency which would be beneficial for osteogenic differentiation.