Abstract
Pharmaceutical tablets are film coated for several reasons, the most common being the enhancement of taste and appearance, the protection of sensitive ingredients and the control of active ingredient release. In this work, we developed a mathematical model that simulates coating spray impact, film formation and drying on pharmaceutical tablet surfaces. To describe spray impingement and liquid film formation we developed a 1-D film-spreading model. To predict the drying of the liquid film, we used the “mixture modeling” theory and the “lubrication approximation” theory to simplify the equations describing the liquid-particle system. The current model allows predicting the thickness of an evaporating coating layer applied on a curved tablet. We performed variance-based sensitivity analysis to study the effect of spray parameters on coating spreading and initial liquid film thickness and to investigate the influence of tablet and film properties on drying.
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