Abstract
Modeling of seizure transitions with ion concentration dynamics
Highlights
It is considered that neuronal synchronization in epilepsy is caused by a chain reaction of synaptic excitation
In order to investigate the respective roles of synaptic and non-synaptic neuronal coupling in seizure transitions, we developed a computational model of hippocampal network, involving extracellular space, realistic dynamics of Na+, K+ and Cl- ions, the glial uptake and diffusion mechanism
We show that in the extended model, strong discharge of inhibitory interneurons may result in long lasting accumulation of extracellular K+, which sustains depolarization of principal cells and causes their pathological discharges. This effect is not present in a reduced, purely synaptic network. These results confirm the experimental hypothesis that increase of inhibitory interneurons firing may lead to increased firing in the pyramidal cells through accumulation of extracellular potassium [2]
Summary
It is considered that neuronal synchronization in epilepsy is caused by a chain reaction of synaptic excitation. Modeling of seizure transitions with ion concentration dynamics
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