Modeling of RNA-only structures.

Abstract

The discovery and design of biologically important RNA molecules has historically outpaced three-structural characterization. I'll describe the Ribosolve method from my and Wah Chiu's groups that can rapidly resolve structures of RNA-only systems through cryo-EM, multidimensional chemical mapping, and computer modeling. The resulting structures give insights into SARS-CoV-2 RNA biology, topological states of complex ribozymes, and how close or far we are from accurate de novo RNA 3D structure prediction.