Abstract
Objectives to study the mechanism of restenosis after the intra-arterial stenting using the original device for modeling of intra-arterial blood flow.
 Material and methods. To perform the experiment, we have created the original device simulating the intra-arterial blood flow. A glass tube of rotameter was the imitation of the arterial vessel. The closed system was filled with the liquid imitating blood, specifically the solution of glycerin the same viscosity as the human blood plasma. Using our original model of intra-artetial blood flow, we were able to study the intra-arterial hemodynamics under different conditions of cardiovascular system functioning, including arrhythmias.
 Results. In extrasystolic arrhythmia, during the spread of the first post-extrasystolic wave, we observed the intensive impact of pressure wave (the indicator was the silk thread) on the vessel walls with forming of reflected and standing waves. Putting the piezo crystal probe of pressure inside the tube, we verified our observations. The increase of pressure during the spread of the first post-extrasystolic wave in multiple measurements had a mean value of 160% in comparison with the pressure during the regular heart rhythm.
 Conclusion. The hydraulic shock appears during the spread of the first post-extrasystolic wave in the arterial vessel. Its effect on hemodynamics grows in case of the frequent extrasystoles and allorhythmia. The mechanical impact of hydraulic shock in extrasystoles can be the starting point of the restenosis onset and progressing in the intra-arterial stent.
Highlights
Objectives – to study the mechanism of restenosis after the intraarterial stenting using the original device for modeling of intra-arterial blood flow
The hydraulic shock appears during the spread of the first post-extrasystolic wave in the arterial vessel
The mechanical impact of hydraulic shock in extrasystoles can be the starting point of the restenosis onset and progressing in the intra-arterial stent
Summary
При прохождении волны первого постэкстрасистолического сокращения в артериальном сосуде возникает гидравлический удар. Механическое воздействие гидравлического удара при экстрасистолии может быть пусковым моментом для начала и прогрессирования рестеноза в установленном внутрисосудистом стенте. Моделирование рестенозов магистральных артерий после внутрисосудистого стентирования. ЦЕЛЬ Изучить особенности механизма возникновения рестенозов на ранее установленном внутрисосудистом стенте с использованием оригинального устройства для моделирования внутриартериального кровообращения.
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