Modeling of intracranial vessels and Simulation of cerebral blood flow

Yingying Yan,Jia Chen,Qiang Du,Li Ke,Xiaodi Ding,L Yang,Z Xu

doi:10.1051/e3sconf/202018503030

Abstract

The stable regulation of cerebral blood flow plays an important role in the normal operation of brain function. The disturbance of cerebral blood flow automatic regulation will lead to brain injury and lead to cerebrovascular disease. Therefore, it is of practical clinical significance to study the fine modeling of intracranial blood vessels. First of all, based on the anatomic structure of the intracranial blood vessels, the above sagittal sinus vein, sigmoid sinus, superior petrosal sinus, transverse sinus and cerebral arterial circle were mainly modeled, the three-dimensional model of cerebral blood flow is constructed. Secondly, the three-dimensional model is given conductivity characteristics. Through the expansion and contraction of cerebral blood vessels to simulate the self-regulation of cerebral blood flow, the simulation method of cerebral blood flow impedance is studied. When the blood flow changes, the brain impedance is calculated. The simulation data shows that the change trend of the electric potential and the whole brain impedance of the outer layer of the brain is consistent with the theoretical analysis. The experimental results show that the impedance curves and changes calculated by the brain model in this study are consistent with the measured impedance results, which shows that the modeling method in this paper is precise and effective, and provides a theoretical basis for further study of cerebral blood flow problems.

Highlights

Brain disease has great harm to human health
If some part of the intracranial blood vessels become occluded by lesions themselves, it will lead to complete blockage of this part of blood flow in a shorter time, and local brain tissue necrosis will occur, long-term intracranial blood supply or abnormal blockage of cerebral blood flow have serious consequences on human life and health and even lead to death[3]
This study aims at the in-depth study of intracranial vascular construction and its own characteristic changes, which is more detailed and accurate than the original model analysis of cerebral blood flow. the fine structure of intracranial vessels is constructed for simulation calculation and research

Summary

Introduction

Brain disease has great harm to human health. The most common brain disease in clinic is cerebrovascular disease. Cerebrovascular disease is a common and frequently occurring disease that endangers human life and health. It has the characteristics of high morbidity, high disability rate, high mortality rate and high recurrence rate. It is a major disease of disability and death in middle-aged and elderly people[1]. If some part of the intracranial blood vessels become occluded by lesions themselves, it will lead to complete blockage of this part of blood flow in a shorter time, and local brain tissue necrosis will occur, long-term intracranial blood supply or abnormal blockage of cerebral blood flow have serious consequences on human life and health and even lead to death[3]. It is of great significance to study the fine modeling of intracranial vessels and the simulation method of cerebral blood flow impedance

Objectives

Findings

Discussion

Conclusion