Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5-8 Days.

Mykola Pinkevych,Martin Tolstrup,Stephen J Kent,Thomas A Rasmussen,Sharon R Lewin,Ole S Søgaard,David A Cooper,Anthony D Kelleher,Deborah Cromer,Miles P Davenport,Ronald Swanstrom

doi:10.1371/journal.ppat.1005740

Mykola Pinkevych, Martin Tolstrup + Show 9 more

Open Access

https://doi.org/10.1371/journal.ppat.1005740

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Abstract

Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5-8 Days.

Highlights

We found that across four cohorts, the best-fit frequency of HIV reactivation from latency was once every 5–8 days
Hill et al.’s modeling demonstrates an alternative approach, in which they start with a fixed rate of reactivation and adjust the model and other parameters to fit their fixed reactivation rate
We show that once the reactivation rate is fitted to all datasets, the results strongly support that the median frequency of HIV reactivation from latency is once every 5–8 days

Summary

Introduction

Hill et al provide a critique[1] of our recent paper, in which we developed two novel methods for estimating the rate of reactivation from latency directly from existing clinical data [2]. We found that across four cohorts, the best-fit frequency of HIV reactivation from latency was once every 5–8 days.

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Conclusion