Modeling of Clostridium histolyticum collagenase inhibitory activity of some sulfonyl-1-amine hydroxamates : A molecular connectivity approach

Abstract

Topological modeling of protease inhibitory activity of some sulfonyl-1-amine hydroxamates which are known to be Clostridium histolyticum collagenase inhibitors has been presented in this paper. Out of the pool of topological indices used Randic and Kier-Hall connectivity indices are found most suitable for the modeling of inhibitory activity.