Abstract
Mass transport of large molecules such as lowdensity lipoprotein (LDL) has received considerable interest in the recent years due to its significance in the early stages of atherosclerosis. Locally elevated concentrations of LDL in the arterial wall are considered to be the initiator of atherosclerotic plaque formation [Lusis AJ, 2006]. Our aim in this study is to account for the effects of the local arterial wall shear stress distribution on the endothelial cell layer in order to accurately calculate LDL transport. For this purpose, we use a realistic 3-D coronary artery segment, where the arterial wall is treated as a single-layer porous medium.
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